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Function of IKKβ in TRIF Signaling. 1 2 Current Issue Accepted Manuscripts Spotlight Free Spotlight Article of Significant Interest in This Issue Minireview Open Access Minireview When Long Noncoding Becomes Protein Coding Recent advancements in genetic and proteomic technologies have revealed that more of the genome encodes proteins than originally thought possible. Specifically, some putative long noncoding RNAs (lncRNAs) have been misannotated as noncoding. Numerous lncRNAs have been found to contain short open reading frames (sORFs) which have been overlooked because of their small size. Many of these sORFs encode small proteins or micropeptides with... Corrine Corrina R. Hartford , Ashish Lal Research Articles Research Article | Spotlight Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether Nrf2 prevents Alzheimer’s disease (AD), AD model App NL-G-F/NL-G-F knock-in ( App NLGF ) mice were studied in combination with genetic Nrf2 induction model Keap1 FA/FA mice. While App NLGF mice displayed shorter latency to... Akira Uruno , Daisuke Matsumaru , Rie Ryoke , Ritsumi Saito , Shiori Kadoguchi , Daisuke Saigusa , Takashi Saito , Takaomi C. Saido , Ryuta Kawashima , Masayuki Yamamoto Research Article Interaction between HuR and circPABPN1 Modulates Autophagy in the Intestinal Epithelium by Altering ATG16L1 Translation Intestinal epithelial autophagy is crucial for host defense against invasive pathogens, and defects in this process occur frequently in patients with inflammatory bowel disease (IBD) and other mucosal disorders, but the exact mechanism that activates autophagy is poorly defined. Here, we investigated the role of RNA-binding protein HuR (human antigen R) in the posttranscriptional control of autophagy-related genes (ATGs) in the... Xiao-Xue Li , Lan Xiao , Hee Kyoung Chung , Xiang-Xue Ma , Xiangzheng Liu , Jia-Le Song , Cindy Z. Jin , Jaladanki N. Rao , Myriam Gorospe , Jian-Ying Wang Research Article hnRNP K Supports High-Amplitude D Site-Binding Protein mRNA ( Dbp mRNA) Oscillation To Sustain Circadian Rhythms Circadian gene expression is defined by the gene-specific phase and amplitude of daily oscillations in mRNA and protein levels. D site-binding protein mRNA ( Dbp mRNA) shows high-amplitude oscillation; however, the underlying mechanism remains elusive. Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its... Paul Kwangho Kwon , Kyung-Ha Lee , Ji-hyung Kim , Sookil Tae , Seokjin Ham , Young-Hun Jeong , Sung Wook Kim , Byunghee Kang , Hyo-Min Kim , Jung-Hyun Choi , Hee Yi , Hyun-Ok Ku , Tae-Young Roh , Chunghun Lim , Kyong-Tai Kim Research Article DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation Hypoxia is a deficiency in oxygen delivery to tissues and is connected to physiological and pathophysiological processes such as embryonic development and cancer. The master regulators of oxygen homeostasis in mammalian cells are the heterodimeric hypoxia-inducible transcription factors 1 and 2 (HIF-1 and HIF-2, respectively). The oxygen-labile HIF-2α subunit has been implicated not only in transcription but also as a regulator of... Sonia L. Evagelou , Olivia Bebenek , Erin J. Specker , James Uniacke Masthead Free Masthead Editorial BoardNEW! ASM Open Data Policy Current Issue volume 40 , issue 6 Table of Contents (PDF) Journal Cover & Description ​ Submit a Manuscript Submit a Manuscript About MCBDr. Peter Tontonoz Editor in ChiefBoard of EditorsMolecular and Cellular Biology ® (MCB) is devoted to the advancement and dissemination of fundamental knowledge concerning the molecular biology of all eukaryotic cells. For Authors ASM Author Center Editorial Board Policies Publication FeesMost Read Most Cited A Feedback Loop between MicroRNA 155 (miR-155), Programmed Cell Death 4, and Activation Protein 1 Modulates the Expression of miR-155 and Tumorigenesis in Tongue Cancer Signaling Pathways Involved in the Regulation of mRNA Translation When Long Noncoding Becomes Protein Coding Centromere Biology: Transcription Goes on Stage More... 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